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Chinese Journal of Rehabilitation Theory and Practice ; (12): 856-858, 2010.
Article in Chinese | WPRIM | ID: wpr-962559

ABSTRACT

@#ObjectiveTo explore the expression of N-cadherin and β-catenin mRNA in human brainstem and supratentorial gliomas. MethodsN-cadherin and β-catenin mRNA expression in 18 cases of brainstem gliomas and 18 cases of supratentorial gliomas tissues were detected with PT-PCR. Resultsβ-catenin mRNA expression was more in human brainstem gliomas than in supratentorial gliomas (t=2.255,P<0.05), but was not significantly different of N-cadherin mRNA (P>0.05). The expression of N-cadherin mRNA in human brainstem gliomas of grades Ⅰ~Ⅱ were less than those in human gliomas of grades Ⅲ~Ⅳ (t=2.711,P<0.05), but was not of β-catenin mRNA (P>0.05). N-cadherin mRNA expression was positively correlated with the β-catenin mRNA expression in either brainstem gliomas or supratentorial gliomas (r=0.480,r=0.809 respectively, P<0.05). ConclusionThe over expressions of N-cadherin and β-catenin may play an important role in the invasion and malignant progress of human brainstem gliomas.

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